Researchers at Tufts University School of Dental Medicine have made significant progress in the development of bioengineered teeth, growing tooth-like structures in the mouths of miniature pigs. The study, published in Stem Cells Translational Medicine, involved using a combination of porcine dental epithelial cells and human dental pulp cells, which were then implanted into the gums of the pigs.
While the structures are not fully formed teeth, the researchers believe they represent a significant step towards creating functional biological tooth replacements. The study highlights the potential of bioengineering to address the limitations of traditional dental implants, which can lead to bone resorption and implant failure over time.
The researchers used a bioreactor to cultivate the cells for a week before implanting them into the pigs' gums. After four months, approximately half of the pigs developed tooth-like structures that contained various natural dental tissues. The structures were smaller than normal pig teeth, but the researchers are optimistic about their potential for future development.
The study's lead author, Pamela Yelick, emphasizes that the structures are not yet fully formed teeth but expresses optimism about the future of bioengineered teeth. The research team plans to continue exploring ways to improve the process and create more complete and functional teeth.