A recent study by Stanford University researchers has identified two distinct periods in which the human body undergoes significant molecular changes: around age 44 and in the early 60s. The research analyzed clinical data and blood samples from 108 participants aged 25 to 75.
The study tracked transcriptomic, proteomic, and metabolomic patterns, as well as microbiome profiles. They found that the abundance of most molecules and microbes doesn't change gradually, but rather shifts abruptly around the ages of 44 and 60.
In the mid-40s, significant changes were observed in molecules related to lipid, caffeine, and alcohol metabolism, as well as in the risk of cardiovascular diseases and skin and muscle dysfunction. In the early 60s, changes were associated with carbohydrate and caffeine metabolism, cardiovascular and skin/muscle diseases, immune regulation, and kidney function.
These findings emphasize the importance of health monitoring around these ages. Researchers suggest that lifestyle adjustments, such as increasing exercise to maintain heart health and muscle mass or reducing alcohol consumption around age 40, may be beneficial.
This research provides a deeper understanding of the aging process and may contribute to the development of early prevention and intervention strategies for age-related diseases.