Yale Study Reveals Neurons' Self-Sufficient Energy Reserves

Recent research from Yale University has uncovered that neurons possess their own glycogen stores, functioning as 'backup batteries' to sustain brain activity during metabolic stress. This discovery challenges the traditional view that glial cells are solely responsible for providing fuel to neurons. The study utilized the microscopic roundworm *C. elegans* and a fluorescent biosensor to monitor neuronal responses to energy stress, introducing the term 'glycogen-dependent glycolytic plasticity' (GDGP) to describe this phenomenon. GDGP is particularly critical when mitochondrial function is compromised. The findings suggest that interventions targeting glycogen metabolism could improve cognitive function in aging populations and lead to new treatments for neurological conditions. The research highlights the importance of understanding the intricate mechanisms that support brain health.