Genetic Study Unveils Secrets of Maria Branyas Morera's Extreme Longevity

Maria Branyas Morera, the world's oldest person who passed away at 117 years and 168 days, became the subject of a comprehensive multiomic study to uncover the secrets of her longevity. Born in San Francisco in 1907, she later moved to Spain. The research, led by scientists from the Josep Carreras Leukaemia Research Institute (IJC) and the Centro de Investigacion Biomedica en Red Cancer (CIBERONC), involved analyzing her genome, proteome, microbiome, and other biological parameters. The study revealed that Maria followed a Mediterranean diet, rich in vegetables, fruits, and olive oil, and was fond of yogurt, which has been linked to reduced colon cancer risk. Her gut flora resembled that of much younger individuals. Genomic analysis showed genetic variants associated with protection against cardiovascular diseases and cancer, along with a strong immune system. Maria also had a lower biological age than her chronological age, as indicated by DNA methylation analysis. Researchers also noted low levels of inflammation and healthy cholesterol levels in her tissues. Maria maintained an active physical, mental, and social life, surrounded by loved ones and engaging in activities like playing the piano until age 108. The research, titled "The Multiomics Blueprint of Extreme Human Lifespan," is available on BiorXiv pending peer review.