Genetic Study Reveals Clues to Maria Branyas's Extreme Longevity

A genetic study explores the secrets behind the extreme longevity of Maria Branyas, who died last August at the age of 117. Branyas was considered the world's oldest person by the Gerontology Research Group since January 2023. The research suggests that her longevity is linked to a "privileged genome," giving her cells the characteristics of younger ones. Researchers found that Branyas had a biological age 17 years younger than her actual age. Samples showed an overrepresentation in genes controlling infections, autoimmune regulation, cancer surveillance, and cognitive function preservation. Dr. Manel Esteller, who led the study, noted her efficient lipid metabolism, associated with prolonged longevity and absence of dementia. The study also revealed a gut microbiota more typical of a child than a centenarian, playing a role in protecting against pathogens and maintaining the immune system. The combination of rare variants in multiple genes and pathways contributed to her reaching 117 years. Born in 1907 in San Francisco, Branyas moved to Catalonia as a child. Her memories included World War I and the Spanish Civil War. She lived in the Residència del Tura d'Olot for over 20 years, surviving two world wars, the Spanish Civil War, and two pandemics, including overcoming COVID-19 at 113 years old.