Researchers from the Institut Català de Nanociència i Nanotecnologia (ICN2) and the Universitat Autònoma de Barcelona (UAB) have developed a groundbreaking technique called "clip-off chemistry" for synthesizing organic macrocycles. This innovative method, published in the journal *Science* on June 19, 2025, allows for the precise "cutting out" of target molecules from crystalline structures.
The clip-off chemistry method uses solid materials as crystalline molds containing strategically placed molecules. These molds have chemical bonds designed to break selectively, releasing macrocycles with high purity. This approach overcomes limitations of traditional methods, enabling the synthesis of complex macrocycles, some with over 160 atoms.
This advancement allows for precise control over ring size and chemical composition, with potential applications in various industries, including food, cosmetics, and controlled drug delivery. This paves the way for innovative materials, devices, and biosensors, offering exciting possibilities for creating advanced materials and impacting fields like nanotechnology and medicine.