A recent study has made a significant breakthrough in understanding the genetic basis of Obsessive-Compulsive Disorder (OCD). Researchers have identified 30 distinct regions within the human genome associated with the disorder. This discovery, published in May 2025, marks a substantial advancement in the field.
The research, involving over 50,000 individuals with OCD and 2 million without, pinpointed approximately 250 genes linked to the condition. These genes are most active in key brain areas, including the hippocampus, striatum, and cerebral cortex. The findings suggest that OCD is influenced by a complex interplay of numerous genes, rather than a single gene.
This research opens avenues for potential new treatments and improved diagnostic methods. Scientists are now exploring existing drugs that could be repurposed to help OCD patients. The study's findings also highlight genetic links between OCD and other mental health conditions, such as anxiety, depression, and Tourette syndrome. This underscores the importance of considering comorbidity in both research and treatment planning.