A recent study by Cnr-Ibiom investigates the potential of polidatin, a natural antioxidant found in plants, to combat cellular alterations associated with Down syndrome. The research highlights polidatin's ability to restore energy metabolism and reduce oxidative stress in cells affected by Down syndrome, suggesting it could help prevent related neurological issues.
The study, published on April 23, 2025, examined cells from spontaneous abortions, some with trisomy 21 (Down syndrome) and others without. Polidatin was found to reactivate mitochondrial bioenergetic activity and reduce excessive oxygen radical production in both cell types. The researchers also observed that polidatin helps prevent DNA damage and premature cellular aging caused by oxidative stress.
The researchers suggest that polidatin could be used as a dietary supplement to manage some symptoms of Down syndrome, potentially starting in early childhood. They note that polidatin has demonstrated no toxic side effects, exhibits stability, is water-soluble, and distributes effectively throughout the body. Furthermore, it lowers levels of miR-155, a molecule linked to mitochondrial dysfunction in Down syndrome.