Researchers are exploring the potential of ultrasound therapy as a non-invasive treatment for drug-resistant depression. This experimental approach focuses on targeting deep brain regions associated with depression. Recent studies indicate that low-intensity focused ultrasound can safely modulate the activity of these brain regions.
A study published in Brain Stimulation by researchers from GHU Paris, Inserm, CNRS, Université Paris Cité and ESPCI Paris-PSL, reveals encouraging outcomes from a five-day treatment using low-intensity focused ultrasound. This innovative technology offers a non-invasive method to modulate the activity of deep brain regions involved in depression. The ultrasound waves propagate through human tissue, remotely stimulating the targeted brain area by mechanical action.
One study involved five patients with severe, drug-resistant depression. The results showed no serious adverse events and excellent tolerance, with patients reporting no discomfort during the sessions. Depression severity scores decreased by over 60% by the fifth day of treatment. Another study, published this month in Molecular Psychiatry, demonstrated that low-intensity focused ultrasound technology can safely and effectively target the amygdala, leading to significant improvements in symptoms of depression, anxiety, and PTSD. These findings suggest that focused ultrasound could offer a valuable alternative for patients who haven't responded to traditional therapies.