Each year, over 550 million people globally contract infections from contaminated food. Salmonella is a common pathogen, posing a challenge due to its resilience within the human body.
Yale University scientists, led by Eduardo Groisman, identified a mechanism aiding Salmonella's survival in hostile environments. The study, published in PNAS, reveals how the bacteria adapts its metabolism under stress, particularly within macrophages.
The researchers manipulated magnesium levels and cAMP molecules in mouse macrophages, simulating infection conditions. This caused Salmonella to shift its carbon source preferences, impacting its growth rate and antibiotic resistance. The findings may lead to new antimicrobial strategies targeting bacterial metabolism.
The study also found that proteins used by Salmonella to alter its metabolism are present in other pathogenic bacteria. This opens possibilities for broader applications in combating similar microorganisms affecting human health. Prevention through hygiene and safe food handling remains crucial in controlling Salmonella infections.