Gene Linked to Obesity Identified in Dogs and Humans

A recent genome-wide association study (GWAS) identified the DENND1B gene as a significant factor in obesity in Labrador retrievers. The study, published in Science Advances, analyzed DNA samples from 241 Labrador retrievers and found a correlation between a mutation in the DENND1B gene and increased body weight, fat accumulation, and reduced energy expenditure. Previous research has also linked variations in DENND1B to body mass index (BMI) in humans. Researchers also found a rare mutation in the DENND1B gene in a severely obese human patient. The findings suggest a shared genetic basis for obesity across species and highlight the interplay between genetic predispositions and environmental factors, such as food availability, in the development of obesity. The study underscores the potential of using animal models, like dogs, to understand and address obesity in both veterinary and human medicine.