Genetic Engineering Creates Woolly Mouse with Mammoth Traits

A US firm, Colossal, has genetically engineered a mouse to exhibit traits similar to the extinct woolly mammoth. This "woolly mouse" has hair three times longer than a regular mouse and lighter fur. The project aims to test hypotheses linking DNA sequences and physical traits that allowed mammoths to adapt to cold climates. Scientists identified ten genetic variants differentiating mammoths from Asian elephants, focusing on traits like hair length, thickness, color, and body fat. They targeted the FGF5 gene and altered three genes related to hair follicle development. The team made eight edits to seven mouse genes using advanced techniques. While Stockholm University's Love Dalén sees this as a significant step in gene editing, Robin Lovell-Badge from the Francis Crick Institute notes the study lacks data on cold tolerance in the modified mice. Colossal plans to resurrect the mammoth, dodo, and Tasmanian tiger, sparking debate over resource allocation and animal welfare.