Recent U.S. research indicates that adjusting the intake of the amino acid isoleucine may extend lifespan. A University of Wisconsin at Madison study explored the impact of reduced isoleucine consumption in mice.
Isoleucine, an essential amino acid sourced from foods like meat, fish, eggs, legumes, dairy, and nuts, is vital for tissue repair, energy, and metabolism. The study revealed that male mice with restricted isoleucine intake lived 33% longer on average, while females saw a 7% increase. Benefits also included better blood sugar regulation, more muscle mass, and fewer cancers.
Researchers advise against uncontrolled isoleucine reduction in humans due to potential disruptions. They suggest carefully selecting foods to manage isoleucine intake and are investigating treatments to modify its activity or absorption without major dietary changes. Further studies are essential to understand these mechanisms in humans and determine the ideal isoleucine level for lifespan extension without health issues. The research highlights the potential of targeted nutrition for longevity.
A study published on April 28th, 2025, in Cell Metabolism, indicates that scientists are one step closer to discovering how to extend human life and slow down aging in humankind.