A genetic study of Maria Branyas, the world's oldest woman who lived to 117, reveals key factors contributing to her exceptional longevity. Researchers found she possessed a "privileged genome" that made her biological age 17 years younger than her chronological age.
Branyas had a gut microbiota resembling that of a young girl, indicating low intestinal inflammation.
Her genome provided protection against cardiovascular and other diseases.
Genetic analysis showed high levels of good cholesterol (HDL) and low levels of bad cholesterol (LDL), along with controlled blood sugar levels.
Her genes effectively managed infections and autoimmune regulation.
She followed a Mediterranean diet, including three yogurts daily, and maintained an active, socially connected lifestyle.
The study suggests that aging and disease can be decoupled under certain conditions. Researchers aim to develop prebiotics and drugs to combat aging, along with tailored diets, based on these findings.